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GHK-Cu produced a concentration-dependent increase in the accumulation of connective tissue, measured as higher collagen and glycosaminoglycan content, higher DNA and protein, and increased collagen mRNAs in the harvested granulation tissue, while an inactive control peptide did not

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This immunohistochemistry displays a significant elevation of albumin in the cortex of AOM mice, which is reduced in mice treated with neutralizing antibodies against TGF (Figure 7c)